5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE
5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE
CAS: 133804-44-1
Molecular Formula: C11H16N2O3S
5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE - Names and Identifiers
5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE - Physico-chemical Properties
| Molecular Formula | C11H16N2O3S |
| Molar Mass | 256.32 |
| Density | 1.302±0.06 g/cm3(Predicted) |
| pKa | -1.76±0.42(Predicted) |
| Storage Condition | Room Temprature |
| In vitro study | Caldaret (MCC-135) is demonstrated to restore Ca 2+ -ATPase activity of the sarcoplasmic reticulum (SR) isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro. |
| In vivo study | Caldaret, an intracellular Ca 2+ handling modulator, limits infarct size of reperfused canine heart. The cardioprotective effect of Caldaret, a novel intracellular Ca 2+ handling modulator that acts through reverse-mode Na + /Ca 2+ exchanger inhibition and potential sarcoplasmic reticulum (SR) Ca 2+ uptake enhancement, against reperfusion injury is investigated. Intravenously infused Caldaret (3 or 30 microg/kg per hour) for 30 min at left circumflex (LCX)-reperfusion markedly reduces infarct size (by 51.3% or 71.9%, respectively). The amelioration of intracellular Ca 2+ handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia. Caldaret (MCC-135) is a new potent compound with beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca 2+ uptake in normal rats, that is observed as increased SR Ca 2+ uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca 2+ uptake all over the range of uptake time. Both initial rate of SR Ca 2+ uptake and the amount of Ca 2+ accumulated in the SR with longer uptake time are increased by Caldaret. |
5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE - References
| biological activity | Caldaret is an intracellular Ca2 modulator that inhibits Na /Ca2 exchange by reverse mode. |
| Target | Na /Ca 2 exchanger |
Last Update：2024-04-09 21:54:55
Supplier List
Product Name: 5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE Visit Supplier Webpage Request for quotation
CAS: 133804-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 133804-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: 5-METHYL-2-(1-PIPERAZINYL)BENZENESULFONIC ACID MONOHYDRATE Visit Supplier Webpage Request for quotation
CAS: 133804-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 133804-44-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History